Harmonised classifications (√ - check mark). Since the source data can be updated at any time while the Brief Profiles are updated at intervals, a slight delay in the publication of information may occur. This section summarises the values related to biodegradation in soil from all registered dossiers for the substance. The bars indicate the number of matching classifications, i.e. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 HW77 Dublin Ireland, Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany, Gas under pressure: refrigerated liquefied gas, Solid: nanomaterial, no surface treatment, Characteristic of sulphur containing compounds, Self-heating substances and mixtures (Cat. Buffer pKa and pH Range Values For preparation of . It is also incompatible with oxidizers. Henry’s Law Constant provides substance information on the substance’s Henry’s Law Constant measured in in Pa.m3.mol-1 at a temperature measured in °C. REACH registration dossiers have greater data requirements (support studies) than notifications under CLP. Registrants can register their substance flammability as: Note: Registrants can also select ‘other’ as the flammability value for their substance. [, Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G: Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Surface tension provides substance information on the surface tension in (milli)Newton per metre in a concentration in (milli)gram per metre and at a temperature measured in °C. Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight). For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. Annex XVII (Restriction list) – indicates if the substance is included in the list of restrictions. Phys. Melting/freezing point at 101 325 Pa provides information on the substance melting/freezing point in °C at a pressure of 101 325 Pa. Melting / freezing point provides substance information on the melting/freezing point in °C at a pressure measured in Pa. Brief Profiles are updated regularly and new information is added when available. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. organic acids – sorted by formula Solubility provides substance information on the substance’s solubility in organic solvents/fat in grams per litre at a temperature measured in °C. If so, the data provided is not processed for the Brief Profile.Prioritization by test species: Processable data for the summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. If so, the data provided is not processed in the Brief Profile. Depending on the structure of the molecule the main layer may be followed by additional layers e.g. Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm. Within the context of REACH, impurities are unintended constituents present in a substance as manufactured. This section summarises the values related to phototransformation in water from all registered dossiers for the substance. This section provides information on the derived no- or minimal effect level (DN(M)EL), the level of exposure above which a human should not be exposed to a substance. If so, the data provided is not processed in the Brief Profile. 'IUPAC name' is the generic field by which substance names are provided in various data submission tools. Data from all dossiers registered and the Classifications and Labelling Inventory (C&L) for the same substance are used to generate the Brief Profile. 1 3. The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance. Aliquam nec erat semper, suscipit libero et, bibendum mauris. Values are generally displayed in milligram per litre. See the official IUPAC website for more information on the International Union of Pure and Applied Chemistry. It is an isomer of isophthalic acid and terephthalic acid. J Appl Toxicol. ... Phthalic Acid – C. 8 H 6 O 4 2.9, 5.4 1.9-6.4 . Values are generally displayed in milligram per litre. This substance is used in the following products: pH regulators and water treatment products and leather treatment products. The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH). This section summarises the values related to toxicity to (terrestrial) arthropods from all registered dossiers for the substance. This section summarises the values related to toxicity to aquatic plants (other than algae) from all registered dossiers for the substance. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Ultraviolet Absorption Spectra of Phthalic Anhydride and Related Substances. Phthalamic acid can be synthesized from the reaction between ammonia and phthalic anhydride by a modified Auger′s method. Table of Acids with Ka and pKa Values* CLAS Acid HA A-Ka pKa Acid Strength Conjugate Base Strength Hydroiodic HI I-Hydrobromic HBr Br-Perchloric HClO4 ClO4-Hydrochloric HCl Cl-Chloric HClO3 ClO3-Sulfuric (1) H2SO4 HSO4-Nitric HNO3 NO3-Strong acids completely dissociate in aq solution (Ka > 1, pKa … Please note: The icons in this section are only meant as visual indicators to help communicate information about the abovementioned critical properties. This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, treatment of articles by dipping and pouring and laboratory work. Within each of these categories, data is prioritised further by duration (in hours), with longer prioritised over shorter. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. If there is a confidentiality claim, an indication is provided with the tag [Confidential]. BOD5 provides substance information on the substance’s BOD5 values displayed in O2 (milli)gram per gram test material. This site is not fully supported in Internet Explorer 7 (and earlier versions). Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight). Active substance approval – indicates if the substance is an approved biocidal active substance. Values are displayed in milligram per litre. Potassium Tartrate – C 4 H 4 K 2 O 6. Y is the check-digit calculated in accordance with the 10-digit ISBN method. , 2015, 17 , 6383 Which determines its two degrees of dissociation Kg 1 and Kg 2.Analytical measured values, dissociation constants measured … Additional information on classification and labelling (C&L) – if available – is derived from REACH registration dossiers submitted by industry. EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. The source of the information is mentioned in the introductory sentence of the hazard statement. LC50 for freshwater invertebrates provides substance information on the substance’s lethal concentration for 50% of the freshwater invertebrates in the test, displayed in milligram per litre. Phthalic acid is an aromatic dicarboxylic acid, with formula C6H4(COOH)2. InChIs consist of text strings comprising different layers and sublayers of information separated by slashes (/). The Agency thus cannot guarantee the correctness of the information displayed. Readily biodegradable but failing the 10-day window. Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. CAS names gives the name(s) provided to ECHA by the Chemical Abstracts Service, a division of the American Chemical Society, where available. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). This section displays the values related to irritation and corrosion from all registered dossiers for the substance. Critical property indentification: Where less than 90% of the notifiers provide the same classification to derive the critical property, the border of this critical property icon is displayed as dashed. Perrin, D. D., Dissociation Constants of Organic Bases in Aqueous Solution, … Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). Values are generally displayed in milligram per kilo soil (dry weight). Applicant’s summary and conclusion – Interpretation of results provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options: Note: Registrants can also select ‘other’ as picklist option for describing the biodegradation values of the substance in water. When submitted by the lead of a joint submission, the classifications may also reveal agreement between companies. The BPR addresses the placing on the market and use of biocidal products, which are used to protect humans, animals, materials or articles against harmful organisms, like pests or bacteria, by regulating the active substances contained in a biocidal product. A recent food safety concern has arisen from the unapproved use of certain phthalates in a broad range of food/nutraceutical ingredients from Taiwan [53]. Please see Registrants/Suppliers details. ... just like you should have done. Log Koc at 20°C provides substance information on the substance’s log Koc adsorption at a temperature 20 °C. Bioaccumulation factor (terrestrial species) provides substance information on the substance’s terrestrial bioaccumulative properties not taking account the dimensions. Dermal route provides substance information on the substance’s acute toxicity via the dermal route. Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions: Prioritisation of display occurs based on the order above. This section summarises the values related to toxicity to aquatic algae and cyanobacteria from all registered dossiers for the substance. Post navigation ← Entropy Calculation for Ideal Gas Elements General Physical Properties : Atomic Size | Melting point | Boiling point → Epub 2003 Oct 25. Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers). These carboxyl groups are directly bonded to the benzene core. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. This section summarises the boiling point values from all registered dossiers for the substance. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method). Epub 2013 Jul 11. H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal. Nat Rev Drug Discov. In most cases, impurities constitute less than 10% of the substance. For example CLH index numbers, CN numbers, deleted CAS numbers, etc. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. Different compositions or impurity profiles often lead to different classifications. Nat Rev Drug Discov. ECHA has no public registered data indicating whether or in which chemical products the substance might be used. With standard SMILES, the name of a molecule is synonymous with its structure: it indirectly shows a two dimensional picture of the molecular structure. Data is generally standardised and displayed in in milligram per kilo of food. This section searches three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Solubility in mg/100g standard fat at 20°C provides substance information on the substance solubility in standard fat in milligram per 100 gram at a temperature of 20°C. Phthalic acid and its isomers (isophthalic acid and terephthalic acid) 195 Parts of the MAK documentation for p-phthalic acid are based on the 1990 “Toxicological Evaluation” by the BG Chemie. Values provided in ppb and Vol% are provided separately. The Agency does not take any responsibility whatsoever for any copyright or other infringements that may be caused by using the information. Note: Registrants can also select ‘other’ as the test species. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. For readability purposes, only the pictograms, signal words and hazard statements referred to in more than 5% of the notifications under CLP are displayed. The Agency thus cannot guarantee the correctness of the information displayed. The use information is displayed per relevant life cycle stage of the substance. The % is based on count of values provided. Phthalic acid,CAS,88-99-3,Phthalic acid suppliers ChemWhat provides identification, property, safety and original manufacturer information for Phthalic acid CAS#: 88-99-3. Chem. Data is generally displayed in milligram per kilo bodyweight. Registrants can choose from the following picklist endpoint conclusions/effect levels: Eye irritation provides substance information on the substance’s irritation effect on the eye. 4409-98-7. When more than one result is available per endpoint the ‘worst case’ or most conservative of all the data values provided are displayed, applying a precautionary principal. ABC corresponds to the atomic number of the most characteristic element or the most characteristic organic group in the molecule. The five highest priority groupings of provided data are displayed in milligram per litre or molar per litre. Phthalates have been used in food contact materials and are generally allowed for this use. EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. phthalic acid has 2 Kas since it is diprotic.. Ka1 = 1.3 X 10^-3. Registrants can register their substance’s flammability as: This section summarises the explosiveness values from all registered dossiers for the substance. Phthalic acid {eq}(PH_2, PH^{-1}, P^{-2}) {/eq} is dibasic with pKa values of 2.95 and 5.41. Provides information if the substance has been identified by one of the following previous EU chemicals regulatory frameworks: The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP (Classification Labelling and Packaging) Regulation. Units and data are normalised when possible and therefore the unit of measure/order of magnitude in the Brief Profile data may not correspond exactly to the one in the registered dossier. The results of matching substance classifications are displayed in percentages of the total number of notifications. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Epub 2003 Apr 30. EC Inventory, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin. This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 per annum. Ka2= 3.1 X 10^-6. The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). More information about classification and labelling can be found in the Regulations section of ECHA website. This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The acute toxicity of the isomers is low. This Brief Profile is covered by the ECHA Legal Disclaimer. It forms white powder, colorless crystals, a colorless solution, and an ionic solid that is the monopotassium salt of phthalic acid. This section summarises the values related to toxicity to microorganisms from all registered dossiers for the substance. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. Registrants can choose from the following (picklist) conclusions: Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above. This main layer contains sublayers for the chemical formula, atom connections and hydrogen atoms. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight). 2003 Aug;306(2):703-8. Results without measurement conditions (pressure) are not processed for the Brief Profile. Otherwise data is displayed as provided by the registrant(s). More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. Registrants can report substance information on viscosity as: Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C. This section summarises the values related to toxicity to birds from all registered dossiers for the substance. Biodegradation in water - screening tests, Biodegradation in water & sediment - simulation tests. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Reduction of phthalic acid with sodium amalgam in the presence of water gives the 1,3-cyclohexadiene derivative. Potassium phthalate. Oxidation reduction potential in mV at 20°C provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature of 20°C. This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance. The quality and correctness of the information remains the responsibility of the data submitter. The brief profile is based on non-confidential data contained in ECHA’s databases at the time of generation. PHTHALIC ACID is a carboxylic acid. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. This section provides information on suppliers, importers or manufacturers of a substance (active and inactive) that have to register their substance under REACH. If so, the data provided is not processed for the Brief Profile. Harmonised C&L– indicates if a European Union harmonised classifications and labelling has been assigned to the substance according to Annex VI to CLP and subsequent ATPs. Under specific conditions, a registrant can claim confidentiality of their identity. Please upgrade your Internet Explorer to a newer version. If multiple values are available, the most conservative value (the highest percentage) is displayed. Ref: YALKOWSKY,SH & DANNENFELSER,RM (1992) ECOSAR Class Program (ECOSAR v0.99h): Class(es) found: Neutral Organics-acid Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond Method : 2.18E-012 atm-m3/mole Group Method: 3.88E-013 atm-m3/mole Henrys LC [VP/WSol estimate using EPI values]: 1.099E-011 atm-m3/mole Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]: Log … Note: Registrants can also select ‘other’ as the unit of measure. Note: If the measurement condition (percentage of organic carbon) is not provided by the registrant for adsorption coefficient Kd, the data provided is not processed for the Brief Profile. More information about the EC Inventory can be found here. Vestibulum tincidunt ultricies libero quis mollis. Data is generally displayed in milligrams per kilogram bodyweight per day. Log Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. The quality and correctness of the information remains the responsibility of the data submitter. More about CAS and the CAS registry can be found here. By summarising the endpoint study data, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. Vapour pressure provides substance information on the vapour pressure in Pa at a temperature measured in °C. This section summarises the partition coefficient values from all registered dossiers for the substance. This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance. List of substances proposed as POPs - Indicates if the substance has been proposed for its inclusion in the Stockholm Convention or if a proposal is under preparation in the European Union. It is possible that the harmonisation is introduced through an amendment to the CLP Regulation. The availability of additional data beyond the five results displayed is indicated by (…).Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). If more than one value is available, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight). REACH registration dossiers notifications. the lowest numerical data) is displayed. Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. The date of the last update corresponds to the publication date of the Brief Profile and not necessarily to the date in which the update occurred in the source data (registered dossiers, the C&L Inventory or a regulatory process). Please see the endpoint help sections for more specific information on the sections or see the ‘Scientific properties’ header for a more complete overview. Pour density provides substance information on the pour density in grams per millilitre at a temperature measured in °C. Unlike the pictograms in the ‘Classification and Labelling’ section, these icons are not determined by any legislative procedure and have the sole purpose of being informative in the context of InfoCards and Brief Profiles. Henry’s law constant can be presented as different types, depending on the units chosen: H dimensionless provides substance information on the substance’s Henry’s Law Constant (dimensionless) at a temperature measured in °C and a pressure measured in Pascal. The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. The availability of additional data beyond the five results displayed is indicated by (…) icon. E5: Acid Dissociation Constants of Organics Last updated; Save as PDF Page ID 6647; … Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. For more information on total tonnage band calculation please consult the Data submission manual. Values are displayed in milligram per litre. If more than one result is available per endpoint, the range of results (min-max, RANGE method) will be presented. The REACH regulatory processes identified for the Brief Profile are: Persistent Organic Pollutants (POPs)The POPs Regulation (EU) 2019/1021 entered into force on 15 July 2019, repealing the previous POPs Regulation (EC) No 850/2004. Buffers in the pH . Phthalic acid is a benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions. Applicant’s summary and conclusion – Interpretation of results. When more than one numerical result is available per endpoint the count is displayed between square brackets. It is a dibasic acid, with pKas of 2.89 and 5.51. Data is generally displayed in milligrams per litre. Please be aware that as additional data is submitted to ECHA, the brief profile will also be updated to reflect the new situation. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. The ‘Regulatory context’ section provides an overview of the regulatory activities that are related to the substance. 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